Editor Profile

Ioannis Kanakis

University/Organization: University of Liverpool

Country: United Kingdom

Biography

Ioannis Kanakis is a PhD holder in the field of Clinical Biochemistry/Bone Matrix Pathobiology with BSc in Chemistry and MSc in Applied Biochemistry â€“ Biotechnology from the University of Patras in Greece. His PhD was carried out in collaboration with medical oncologists in clinical trials for the study of established bone biomarkers in serum and urine, the development of new biochemical markers of bone metastatic cancer and the clinical evaluation of pharmaceutical compounds (zoledronic acid, ZA), administered in patients with breast cancer-induced bone disease As a postdoctoral scientist since April 2013 at the Wellcome Trust Centre for Cell-Matrix Research, University of Manchester in UK, He was involved in the preclinical drug development of a novel protein-based immunomodulator (TSG-6) as therapeutic for post-menopausal osteoporosis, funded by MRC. Since November 2015, Ioannis Kanakis working at the Institute of Ageing & Chronic Disease in Liverpool as a Postdoctoral Fellow. This Arthritis Research RUK-funded research grant involves the generation and maintenance of novel transgenic mice for the investigation of specific genes in the development as well as the therapy of osteoarthritis.

Research Interest

Ioannis Kanakis main research interest is how breast cancer cells are colonized on bone tissue to promote skeletal metastases and especially the role of the extracellular matrix in this process. Although, this metastatic spread occurs in the most cases of advanced breast cancer, many of patients to not develop osseous metastasis and therefore, a personalized approach should be taken into consideration. As a postdoctoral researcher in the UK, His skills were broadened and enriched in the fields of novel drug development, in vivo prelinical evaluation and gene therapy. Ioannis Kanakis have experience in the major human bone/cartilage diseases (bone metastasis, osteoporosis and osteoarthritis) as well as in the field of miRNAs in Musculoskeletal Biology. His expertise of developing state-of-the-art bioanalytical assays for biomarker discovery, cell-based assays for in vitro drug testing/signaling pathways and his in depth knowledge of tumor and bone cells microenvironment have been widely recognized in academia via my highly cited published work.