Diabetes is a systemic disorder that affects almost all body systems, either directly or indirectly through its complications. Among the acute complications, acute metabolic derangements, urinary tract infections, skin and other infections with side effects of drugs are important. The major chronic complications are retinopathy, nephropathy, neuropathy, ischemic heart disease, cerebro-vascular accidents (CVA), blood circulation disorders and dermal lesions. Between these, blood circulation disorders are the major morbidities. The effects of diabetes on healing are diverse, multi-factorial, complex and inter-related. Wound healing is a major concerned with diabetes, more with type II than compared with type I. In fact, diabetes affects almost all stages of wound healing to some extent. This editorial discusses the underlying mechanisms that causes delayed wound healing, as those have been extensively investigated in the past few decades.